Dendrobium: The next big thing?
Stimulated pre-workout users seek gratification from the ingredients they are ingesting. If that “feel good” sensation is what you’re seeking you’re bound to come across dendrobium. 1,3 Dimethylamylamine had its reign on the supplement industry, but due to concerns, its being pulled from several pre-workouts. Is dendrobium the next big thing?
Pre-workout enthusiasts have generally been delighted by Driven Sports’ pre-workout product Craze. One of the main components of Craze is dendrobium: Dendrobex™ (Dendrobium Extract) (Stem) (Concentrated For Alkaloid Content Including Dendrobine, Dendroxine, Dendramine, B-Phenylethylamine, N,N-Dimethyl-B-Phenylethylamine, And N,N-Diethyl-B-Phenylethylamine) 
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These alkaloids have shown anti-cancer, anti-oxidant, and neuroprotective roles.  They are also responsible for the heightened sense of well-being many users of products like Driven Sports Craze experience.
One thing that will be mentioned later on is Dendrobium’s ability to increase users’ well-being through upsurges in dopamine and serotonin, two neurotransmitters that greatly affect mood. Dendrobium also has a stimulating effect on the central nervous system.
The Dendrobium Feel-Good Effect
One component of Dendrobium is Phenylethylamine (PEA): 
The phenylethylamine drugs are chemically related to amphetamines. Phenylethylamine have varying degrees of hallucinogenic and CNS stimulant effects, which are likely related to their ability to release serotonin and dopamine, respectfully. 
This component stimulates the “feel-good” hormones in serotonin and dopamine, leading to a very cheerful mood. Many users of Dendrobium experience a significant uplift in mood and spirit. This can lead to being more productive throughout the day and even having the ambition to push yourself harder in the gym. Some users also report a strong reduction in appetite. This may be associated with Dendrobium’s ability to increase serotonin.
PEA’s affect on mood can be noted by a study conducted by Rush University which shows PEA’s ability to act as an anti-depressant:
Fourteen patients with major depressive episodes that responded to PEA treatment (10-60 mg orally per day, with 10 mg/day selegiline to prevent rapid PEA destruction) were reexamined 20 to 50 weeks later. The antidepressant response had been maintained in 12 patients. Effective dosage did not change with time. There were no apparent side effects. PEA produces sustained relief of depression in a significant number of patients, including some unresponsive to the standard treatments. PEA improves mood as rapidly as amphetamine but does not produce tolerance. 
Dendrobium also has the ability to increase one’s mental awareness and energy levels. Its central nervous system stimulatory effects are noted by above by it various PEA constitutes. Some of this may be associated with its ability to increase dopamine.
Fat Burning Effect
Did you know this Dendrobium is not only a good “pick me up” supplement, but it can also aid in fat loss?
… extract of Dendrobium moniliforme (DM) on metabolic disorders both in vitro and in vivo. DM extract and its ethyl acetate (EA) fraction selectively stimulated the transcriptional activity of PPARα and regulated expression of genes involved in lipid metabolism in HepG2 hepatocytes, which led to increased mitochondrial and/or peroxisomal fatty acid β-oxidation. 
Will we see Dendrobium be included in many fat loss agents in the future? The current research available warrants its inclusion. More research will probably need to be conducted on this supplement before we see widespread use.
Dendrobium and Beta Alanine/Taurine
You may have heard that it’s best to avoid dosing beta alanine and taurine around the same time you supplement with Dendrobium. Through one study  and multiple anecdotal experiences, this appears to be true. The combination can cause nausea and just an upset stomach type feel. None of these are appreciable at any time of the day, especially when working out. This could lead to an overall decrease in performance.
- Driven Sports – Craze PreWorkout
- Review of research on Dendrobium, a prized folk medicine, Ng TB, Liu J, Wong JH, Ye X, Wing Sze SC, Tong Y, Zhang KY.
- 1-phenethylamine – Compound Summary
- Glen R. Hanson, Peter J. Venturelli, Annette E. Fleckenstein (2005-11-03). “Drugs and society (Ninth Edition)”. Jones and Bartlett Publishers. ISBN 978-0-7637-3732-0. Retrieved 2013-01-02.
- Sustained antidepressant effect of PEA replacement, Sabelli H, Fink P, Fawcett J, Tom C.
- Dendrobium moniliforme extract regulates glucose and lipid metabolism through activation of peroxisome proliferator-activated receptor α, Woojung Lee, Goo Yoon, Yujung Jung, Youngsic Jeon, Ye Ran Hwang, Ki Sung Kang, Yong Kee Kim, Sung Hee Um and Su-Nam Kim.
- Dendrobine, an antagonist of beta-alanine, taurine and of presynaptic inhibition in the frog spinal cord, Kudo Y, Tanaka A, Yamada K